Title of article
T3P (propylphosphonic anhydride) mediated conversion of Nα-protected amino/peptide acids into thioacids
Author/Authors
Madhu، نويسنده , , Chilakapati and Basavaprabhu and Vishwanatha، نويسنده , , T.M. and Sureshbabu، نويسنده , , Vommina V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1406
To page
1409
Abstract
A general, mild and an efficient protocol, which makes use of T3P as an acid activator for the synthesis of Nα-protected amino/peptide thioacids from corresponding acids in the presence of finely ground Na2S as hydrosulfide ion donor is described. The protocol employed significantly increases the overall efficiency as the yield, reaction duration and purity of even sterically hindered amino acids.
Keywords
Propylphosphonic anhydride , N?-Protected amino/peptide thioacids , Dipeptide synthesis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880273
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