Title of article :
Asymmetric induction in domino Heck-aza-Michael reactions
Author/Authors :
Priebbenow، نويسنده , , Daniel L. and Stewart، نويسنده , , Scott G. and Pfeffer، نويسنده , , Frederick M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68–81%) with moderate to high diastereoselectivity (up to 92% de).
Keywords :
PALLADIUM , stereoselective , Domino reaction , N-heterocycles
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
