Title of article
Cyclopentane-1,2-dione bis(tert-butyldimethylsilyl) enol ether in asymmetric organocatalytic Mukaiyama–Michael reactions
Author/Authors
Indrek Reile، نويسنده , , Indrek and Paju، نويسنده , , Anne and Kanger، نويسنده , , Tُnis and Jنrving، نويسنده , , Ivar and Lopp، نويسنده , , Margus، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
1476
To page
1478
Abstract
Cyclopentane-1,2-dione bis(tert-butyldimethylsilyl) enol ether readily undergoes organocatalytic reactions with α,β-unsaturated aldehydes resulting in Mukaiyama–Michael adducts which, after reduction of the aldehyde group and deprotection result in chiral 1,2-diketones (in mono-enolic form) in good yields (up to 66%) and with high stereoselectivity (up to 94% ee).
Keywords
2-dione bis(tert-butyldimethylsilyl) enol ether , ? , ?-Unsaturated aldehyde , Mukaiyama–Michael reaction , organocatalysis , 2-dione , Cyclopentane-1 , Cyclopentane-1
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880291
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