Author/Authors :
Spencer، نويسنده , , John and Patel، نويسنده , , Hiren and Amin، نويسنده , , Jahangir and Callear، نويسنده , , Samantha K. and Coles، نويسنده , , Simon J. and Deadman، نويسنده , , John J. and Furman، نويسنده , , Christophe and Mansouri، نويسنده , , Roxane and Chavatte، نويسنده , , Philippe and Millet، نويسنده , , Régis، نويسنده ,
Abstract :
A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.
Keywords :
Microwave-assisted synthesis , Parallel synthesis , Flow chemistry , oxazoles
