Title of article
On the power of super acid—iodination of aromatic ring in the presence of imidazole moiety of the potent gamma secretase modulators (GSM) en route to tritium labeling
Author/Authors
Mandal، نويسنده , , Mihirbaran and Lavey، نويسنده , , Carolee and Buevich، نويسنده , , Alexei V. and Zhu، نويسنده , , Zhaoning and Stamford، نويسنده , , Andrew W. and Liu، نويسنده , , Xiaoxiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
1725
To page
1727
Abstract
Two advanced leads from the GSM program were iodinated selectively on the aromatic ring in the presence of an imidazole fragment using Olah’s reagent—the combination of NIS and trifluoromethanesulfonic acid. These iodinated compounds were tritium labeled via a transition metal catalyzed sodium borotritide reduction for the purpose of metabolite studies.
Keywords
Superacid , iodination , Superelectrophile , Olah’s reagent , electrophile
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880387
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