Deoxy derivatives of L-like 5′-noraristeromycin

Several base variations of 2′- and 3′-deoxy derivatives of (+)-4′-deoxy-5′-noraristeromycin have been prepared from enantiomerically pure precursors following standard purine nucleoside construction. These carbocyclic nucleosides were evaluated against hepatitis B virus (HBV) and found to be inactive. No cytotoxicity to the cell line was observed.