Nano indium oxide: an efficient catalyst for the synthesis of 1,2-disubstituted benzimidazoles in aqueous media

Synthesis of 1,2-disubstituted benzimidazoles has been developed by the condensation of diamine with aldehydes using nano In2O3 as an efficient catalyst under mild reaction conditions in aqueous media. The procedure is applicable to aryl, aliphatic, heteroaryl aldehydes. In2O3 nanoparticles are recyclable without the loss of significant catalytic activity.