Title of article
Asymmetric synthesis of both the enantiomers of antidepressant venlafaxine and its analogues
Author/Authors
Bhuniya، نويسنده , , Rajib and Nanda، نويسنده , , Samik، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
1990
To page
1992
Abstract
Chemoenzymatic asymmetric synthesis of antidepressant agent venlafaxine and its analogue have been reported in this communication. The main highlight of the reported synthesis is the stereoselective synthesis of cyanohydrins by (S)-hydroxynitrile lyase (Hevea brasiliensis) followed by lipase catalyzed kinetic resolution.
Keywords
Hydroxynitrile lyase , Lipase catalyzed kinetic resolution , asymmetric synthesis , Antidepressants
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880510
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