Title of article :
A uronic acid analogue of isofagomine lactam as a nanomolar glucuronidase inhibitor
Author/Authors :
Lindbنck، نويسنده , , Emil and Zhou، نويسنده , , You and Lَpez، نويسنده , , سscar and Fernلndez-Bolaٌos، نويسنده , , José G. and Pedersen، نويسنده , , Christian Marcus and Bols، نويسنده , , Mikael، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
The synthesis of (3S,4R,5R)-3,4-dihydroxypiperidin-2-one-5-carboxylic acid (‘isofagomine lactam uronate’) from d-arabinose is reported. The product is a potent inhibitor in the low nanomolar range (Ki 36 nM) for bovine liver β-glucuronidase.
Keywords :
Selective oxidation , Bisacetoxyiodobenzene , 6-Tetramethyl-piperidin-1-yl)oxyl , ?-glucuronidase , ?-Glucuronidase inhibitor , (2 , 2 , 6
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
