Title of article :
N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN
Author/Authors :
Fan، نويسنده , , Ye-Cheng and Du، نويسنده , , Guang-Fen and Sun، نويسنده , , Wan-Fu and Kang، نويسنده , , Wei and He، نويسنده , , Lin، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
N-Heterocyclic carbenes (NHCs) have been served as efficient catalysts for cyanomethylation of carbonyl compounds. In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give β-hydroxynitriles in moderate to high yields.
Keywords :
N-heterocyclic carbene , carbonyl compounds , Cyanomethylation , Trimethylsilylacetonitrile , ?-Hydroxynitriles
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
