Title of article
Water-promoted one-pot vinylogous Mannich-type reaction of trimethylsilyloxyfuran
Author/Authors
P. and Landelle، نويسنده , , Grégory and Claraz، نويسنده , , Aurélie and Oudeyer، نويسنده , , Sylvain and Levacher، نويسنده , , Vincent، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
2414
To page
2416
Abstract
Water, produced in situ during the formation of imines from aldehydes 1 and amines 2, is employed to promote the one-pot Mannich reaction of trimethylsilyloxyfuran 3a without addition of extra solvent or catalyst. This clean and quick reaction allows the obtention of a series of 5-substituted γ-butenolides 4 with good yields and modest diastereomeric ratio. A large panel of substituents is tolerated ranging from aliphatic chains to aromatic or heteroaromatic rings.
Keywords
Trimethylsilyloxyfuran , Vinylogous Mannich-type reaction , one-pot reaction , solvent-free , imines
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880679
Link To Document