Title of article
Synthesis of novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds
Author/Authors
Nicolas Leflemme، نويسنده , , Nicolas and Stoit، نويسنده , , Axel R. and Borghese، نويسنده , , Alfio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
2432
To page
2435
Abstract
With the aim to enrich our ‘privileged structure’-based library, novel 2H-spiro[1-benzofuran-3,4′-piperidin]ol scaffolds were prepared. The method involved a key intramolecular Heck cyclization which was successfully applied for three series of compounds. The desired scaffolds were obtained in overall yields of 42–53%.
Keywords
Scaffold , Privileged structure , SNAr , Intramolecular Heck reaction
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880690
Link To Document