Title of article
Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method
Author/Authors
Burgula Srinivas، نويسنده , , Laxmi Narayana and Radhakrishnan، نويسنده , , K. and Kundu، نويسنده , , Lal Mohan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
2639
To page
2642
Abstract
Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined.
Keywords
Nucleobases , Pyrimidine , Lewis acid , microwave , DNA damage
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880779
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