Title of article
Asymmetric α-hydroxy ketone synthesis by direct ketone oxidation using a bimetallic palladium(II) complex
Author/Authors
Hamed، نويسنده , , Othman A. and El-Qisairi، نويسنده , , Arab and Qaseer، نويسنده , , Hanan and Hamed، نويسنده , , Emad M. and Henry، نويسنده , , Patrick M. and Becker، نويسنده , , Daniel P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
2699
To page
2701
Abstract
The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.
Keywords
asymmetric synthesis , Acyloin , ?-Hydroxyketone , Palladium catalysis , Bimetallic palladium
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880801
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