Title of article
Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins
Author/Authors
Ghosh، نويسنده , , Shibaji K. and Butler، نويسنده , , Mark S. and Lear، نويسنده , , Martin J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
2706
To page
2708
Abstract
The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway.
Keywords
Threitol , Sharpless , Tetraols , Dudley , Enantiodivergent , antibiotic , Microbial , Mevalonate , malaria , Erythritol , parasitic
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880805
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