Author/Authors :
Kimishima، نويسنده , , Aoi and Hirose، نويسنده , , Tomoyasu and Sugawara، نويسنده , , Akihiro and Matsumaru، نويسنده , , Takanori and Nakamura، نويسنده , , Kaoru and Katsuyama، نويسنده , , Ken and Toda، نويسنده , , Masaki and Takada، نويسنده , , Hirokazu and Masuma، نويسنده , , Rokuro and ?mura، نويسنده , , Satoshi and Sunazuka، نويسنده , , Toshiaki، نويسنده ,
Abstract :
Luminamicin (1) was found to exhibit selective antibacterial activity against anaerobic bacteria by our group in 1985. The concise structure of 14-membered lactone of 1 was synthesized. Construction of a versatile enol ether moiety was achieved by Stille cross coupling via hydrostanylation of the ethynyl ether, and a maleic anhydride moiety was derived from the furan constitution by the oxidation after the macrolactonization at a late-stage.
Keywords :
Antianaerobic activity , 14-Membered macrolactone , Conjugated enol ether , Luminamicin , Coloradocin
