Title of article :
1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: a new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine
Author/Authors :
Aouadi، نويسنده , , Kaïss and Jeanneau، نويسنده , , Erwann and Msaddek، نويسنده , , Moncef and Praly، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
1,3-Dipolar cycloaddition of a chiral nitrone derived from (−)-menthone to (E)-1,4-dichlorobut-2-ene was the key step in a novel 5 step synthesis of (2S,3S,4R)-4-hydroxyisoleucine, obtained in 21% overall yield with high enantiopurity.
Keywords :
3-dipolar cycloaddition , Chiral nitrone , 1 , 4-hydroxyisoleucine , Isoxazolidines , menthone
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
