Title of article :
A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones
Author/Authors :
Hitchin، نويسنده , , James R. and Hamilton، نويسنده , , Niall M. and Jordan، نويسنده , , Allan M. and Lyons، نويسنده , , Amanda J. and Ogilvie، نويسنده , , Donald J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
A novel scalable stereoselective synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones has been developed using phthalimide based Mitsunobu chemistry. In all four cases, the products were isolated as single diastereoisomers in high chemical yield and purity without the need for chromatography at any stage in their syntheses.
Keywords :
Steroid , stereoselectivity , Mitsunobu reaction , Phthalimide , scalability
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
