Title of article
Bromodimethylsulfonium bromide (BDMS)-mediated Lossen rearrangement: synthesis of unsymmetrical ureas
Author/Authors
Yadav، نويسنده , , Deepak K. and Yadav، نويسنده , , Arvind K. and Srivastava، نويسنده , , Vishnu P. and Watal، نويسنده , , Geeta and Yadav، نويسنده , , Lal Dhar S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
2890
To page
2893
Abstract
Bromodimethylsulfonium bromide (BDMS) was found to be a very efficient reagent for Lossen rearrangement of hydroxamic acids to the corresponding isocyanates which were subsequently trapped in situ with various amines to afford unsymmetrical ureas in good to excellent yields (64–89%). The protocol is experimentally simple, mild, and represents valuable alternative to the existing methods for in situ activation of hydroxamic acids promoting Lossen rearrangement.
Keywords
Bromodimethylsulfonium bromide (BDMS) , Lossen rearrangement , Hydroxamic acids , Isocyanates , Unsymmetrical ureas
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880886
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