Title of article
New scalable and eco-friendly synthesis of gingerols
Author/Authors
Vijendra Kumar، نويسنده , , N. and Srinivas، نويسنده , , P. and Bettadaiah، نويسنده , , B.K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
2993
To page
2995
Abstract
Synthesis of 6-gingerol and its congeners 7- and 9-gingerols has been achieved from eugenol by a new scalable and eco-friendly protocol. The key steps are functionalization of eugenol to the nitro compound and its reaction under optimized condition with terminal alkenes to afford intermediate isoxazolines. The latter on catalytic hydrogenation in presence of Raney nickel afford corresponding gingerols in good yields.
Keywords
6-Gingerol , Hydroboration , Eugenyl iodide , Isoxazolines , olefins , Reduction , Eugenol
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880929
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