Highly chemoselective palladium-catalyzed Sonogashira coupling of 5-iodouridine-5′-triphosphates with propargylamine: a new efficient method for the synthesis of 5-aminopropargyl-uridine-5′-triphosphates

An efficient palladium-catalyzed Sonogashira coupling of 5-iodouridine-5′-triphosphates with propargylamine is described. The catalytic reaction is highly chemoselective that affords exclusively 5-aminopropargyl-uridine-5′-triphosphates in good yields with high purities (>99.8%).