Title of article
Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water
Author/Authors
Keivanloo، نويسنده , , Ali and Bakherad، نويسنده , , Mohammad Javad Nasr Isfahani، نويسنده , , Hossein and Esmaily، نويسنده , , Somayeh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
3126
To page
3130
Abstract
A highly efficient one-pot synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles is presented. The reaction of 5-(alkyl-arylamino)-6-chloropyrazine-2,3-dicarbonitriles with phenylacetylene, catalyzed by Pd–Cu, in the presence of SDS as the surfactant in water, leads to the desired products in good-to-high yields.
Keywords
3-b]pyrazine , surfactant , cross-coupling , phenylacetylene , Palladuim catalyzed
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880979
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