Title of article
Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one
Author/Authors
Velvadapu، نويسنده , , Venkata and McDonnell، نويسنده , , Mark E. and Jaffe، نويسنده , , Eileen K. and Reitz، نويسنده , , Allen B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
3144
To page
3146
Abstract
3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.
Keywords
furanone , Mutagenicity , Chlorine , Mutagen X , Mucochloric acid
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880985
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