Title of article
High-speed microwave assisted synthesis of SEA0400—a selective inhibitor of the Na+/Ca2+ exchanger
Author/Authors
de la Cruz، نويسنده , , Gemma Guedes and Groschner، نويسنده , , Klaus and Oliver Kappe، نويسنده , , C. and Glasnov، نويسنده , , Toma N. Glasnov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
3731
To page
3734
Abstract
An efficient and rapid five-step synthesis of SEA0400, a selective Na+/Ca2+ exchanger (NCX) inhibitor, using controlled microwave heating is reported. In addition, a novel three-step route omitting the key Baeyer–Villiger oxidation/hydrolysis sequence has been developed.
Keywords
Baeyer–Villiger oxidation , Williamson ether synthesis , Microwave-assisted synthesis , Continuous-flow hydrogenation , Process intensification , SEA0400
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881229
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