Author/Authors :
Putra، نويسنده , , Masteria Yunovilsa and Ianaro، نويسنده , , Angela and Panza، نويسنده , , Elisabetta and Bavestrello، نويسنده , , Giorgio and Cerrano، نويسنده , , Carlo and Fattorusso، نويسنده , , Ernesto and Taglialatela-Scafati، نويسنده , , Orazio، نويسنده ,
Abstract :
Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two new alkaloids, named sinulasulfoxide (1) and sinulasulfone (2), characterized by an amide linkage between a phytanic acid moiety and an uncommon sulfur-containing unit. Their complete stereostructures were elucidated by interpretation of MS and NMR data along with CD analysis and chemical modifications. Sinulasulfoxide (1) proved to moderately inhibit LPS-induced NO release.
Keywords :
Sulfur-containing compounds , Sinularia , Alkaloids , iNOS inhibition , Soft coral
