Author/Authors :
Estrada، نويسنده , , Gizelda O.D. and Flores، نويسنده , , Marcella C. and da Silva، نويسنده , , Joaquim F.M. and de Souza، نويسنده , , Rodrigo O.M.A. and e Miranda، نويسنده , , Leandro S.M.، نويسنده ,
Abstract :
In the present work we report a high selective synthesis of the bicyclic core present in an important angiotensin II inhibitor family of drugs (Sartans) under continuous flow conditions. The key step in our approach was a Suzuki–Miyaura coupling using for the first time the recently described 4-toluylboronic acid MIDA ester.
Keywords :
Sartan , 4-Toluylboronic acid MIDA ester , Suzuki–Miyaura cross-coupling , Continuous flow
