Author/Authors :
Miyoshi، نويسنده , , Tetsuya and Sato، نويسنده , , Shohei and Tanaka، نويسنده , , Hiroya and Hasegawa، نويسنده , , Chihiro and Ueda، نويسنده , , Masafumi and Miyata، نويسنده , , Okiko، نويسنده ,
Abstract :
The efficient one-pot umpolung α-phenylation of ketones via N-alkenylisoxazolidine is described. When the various ketones are treated with triphenylaluminum prepared from phenylmagnesium chloride and AlCl3 in the presence of isoxazolidine, the desired products are obtained in good to moderate yield. This method is equivalent to a direct α-arylation reaction of carbonyl groups.
Keywords :
umpolung , Ketone , one-pot reaction , Enamine , Phenylmagnesium chloride
