Title of article
Enantioselective reductive aldol reaction using tertiary amine as hydride donor
Author/Authors
Osakama، نويسنده , , Kazuki and Sugiura، نويسنده , , Masaharu and Nakajima، نويسنده , , Makoto and Kotani، نويسنده , , Shunsuke، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
4199
To page
4201
Abstract
An efficient method was developed for the enantioselective reductive aldol reaction of α,β-unsaturated ketones with aldehydes in the presence of a Lewis base catalyst; conjugate reduction using a tertiary amine and trichlorosilyl triflate, followed by an aldol reaction with BINAP dioxide (BINAPO) as an organocatalyst, gave the corresponding product in high yield with high stereoselectivity.
Keywords
aldol reaction , Asymmetric catalysis , Phosphine oxide , Tertiary amine , Conjugate reduction
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881451
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