Title of article :
sp3 C–H bond functionalization of methyl n-alkyl ketones [MeCOCnH2n+1 (n = 6–8)] as a novel method for the one-pot regioselective synthesis of ‘bifunctional alkanes’ with remote functional groups
Author/Authors :
Akhrem، نويسنده , , Irena S. and Afanas’eva، نويسنده , , Lyudmila V. and Kagramanov، نويسنده , , Nikolai D. and Petrovskii، نويسنده , , Pavel V.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Selective one-pot functionalization of methyl n-alkyl ketones, CnH2n+1COMe (n = 6–8) involving C-sp3–H bond cleavage with CO and various nucleophilic substrates [iPrOH, BuCH(Et)CH2OH, CF3CH2OH, (CF3)(Me)CHOH, H(CF2)2CH2OH, HCCCH2OH, furan, thiophene, and anisole] in the presence of the superelectrophilic system CBr4·2AlBr3 has been performed for the first time.
Keywords :
Functionalized ketones , n-Alkyl methyl ketones , Functionalization , Superelectrophiles
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
