Title of article
Monanchomycalins A and B, unusual guanidine alkaloids from the sponge Monanchora pulchra
Author/Authors
Makarieva، نويسنده , , Tatyana N. and Tabakmaher، نويسنده , , Ksenya M. and Guzii، نويسنده , , Alla G. and Denisenko، نويسنده , , Vladimir A. and Dmitrenok، نويسنده , , Pavel S. and Kuzmich، نويسنده , , Alexandra S. and Lee، نويسنده , , Hyi-Seung and Stonik، نويسنده , , Valentin A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4228
To page
4231
Abstract
New pentacyclic guanidine alkaloids, monanchomycalins A (1) and B (2) were isolated from the marine sponge, Monanchora pulchra and their structures elucidated using NMR, HRMALDI-TOF-MS, and HRESI MS, as well as by chemical transformations of 1. Compounds 1 and 2 exhibited potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 120 and 140 nM, respectively.
Keywords
Pentacyclic guanidine alkaloids , Monanchomycalins , spermidine , Marine sponge , Monanchora pulchra
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881465
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