Author/Authors :
Tran-Dube، Michelle B. نويسنده , , Michelle and Sach، نويسنده , , Neal and Ninkovic، نويسنده , , Sacha and Braganza، نويسنده , , John F. and Huang، نويسنده , , Qinhua and Johnson، نويسنده , , Benjamin V.C. Collins، نويسنده , , Michael Raymond، نويسنده ,
Abstract :
The synthesis of 3-(6-chloropyrazin-2-yl)pyrazolo[1,5-a]pyridine from an enol ether and 4-substituted 1-aminopyridinim iodides via a 3+2 cycloaddition is presented. A high throughput reaction screen was used to optimize the yield of the cycloaddition. This protocol is operationally simple, scalable, proceeds at room temperature, and the reaction profiles are very clean.
Keywords :
5-a]pyridine , 1-Aminopyridinium , Enol ether , 3+2 Cycloaddition
