Title of article :
Regioselective assembly of 3,4-dihydroisoquinoline derivatives
Author/Authors :
Gao، نويسنده , , Zhongli and Davis، نويسنده , , Larry and Chiang، نويسنده , , Yulin and Munson، نويسنده , , Randall and Hendrix، نويسنده , , James A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
A facile two-step sequence (9→10→1) of regioselective assembly of 3,4-dihydroisoquinoline derivatives 1 is reported. The halogen derivatives provide opportunity for Suzuki, Buchwald, and related coupling reactions useful for expanding the scaffold and lead optimization in drug discovery.
Keywords :
Alkaloids , Bischler–Napieralski reaction , Pictet–Spengler reaction , 3 , 4-Dihydroisoquinoline
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
