Title of article
PEG grafted AM SURE™ resin and its application to solid-phase peptide synthesis
Author/Authors
Kim، نويسنده , , Mira and Park، نويسنده , , Yong-Sun and Shin، نويسنده , , Dong-Sik and Lee، نويسنده , , Song and Lee، نويسنده , , Yoon-Sik، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4576
To page
4579
Abstract
PEGylated core–shell type resin (PEG-AM SURE) was developed by modifying the surface of AM SURE™ resin with diamino PEG. The conditions for the PEG coupling reaction were optimized by adjusting PEG chain cross-linking and the amount of free amino groups to ensure a enough loading level of functional groups on the resin (>0.30–0.39 mmol NH2/g). The resulting PEG-AM SURE resin showed better performance than conventional resins during solid-phase peptide synthesis of JR10-mer and β2m58–69 12-mer.
Keywords
Polymer support , Core–shell type resin bead , Solid-phase peptide synthesis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881618
Link To Document