Synthesis of a fully functionalized pillar[5]arene by ‘click chemistry’ and its effective binding toward neutral alkanediamines

A fully functionalized pillar[5]arene was synthesized by ‘click chemistry’ and the possible synthetic strategies have been discussed. The host showed effective binding affinities toward neutral alkanediamines (Ka >103 M−1), which are much larger than those observed for simple methyl-substituted pillar[5]arene.