Optimised conditions for styrene syntheses using Suzuki–Miyaura couplings and catalyst-ligand-base pre-mixes

Optimised conditions are reported for Suzuki–Miyaura couplings between N-tosyl-2-bromo-benzylamines and -phenethylamines with vinylboronic acids, using pre-mixes of catalyst, ligand and base, leading to the corresponding 2-tosylaminomethyl- and 2-tosylaminoethyl-styrenes in generally excellent yields, using microwave excitation at 100 °C.