Title of article
Alkylation of 3,5-dichloro-2(1H)-pyrazinones using malonate esters
Author/Authors
Mishra، نويسنده , , Nigam M. and Peshkov، نويسنده , , Vsevolod A. and Pereshivko، نويسنده , , Olga P. and Modha، نويسنده , , Sachin G. and Van der Eycken، نويسنده , , Erik V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
4676
To page
4678
Abstract
An efficient base-promoted 3-alkylation of 3,5-dichloro-2(1H)-pyrazinones with various malonate esters is described. The method constitutes a simple example of a C–C bond forming process at the 3-position of the pyrazinone core allowing to attain 3-substituted pyrazinones in good to high yields. 3-Alkylation of 3,5-dichloro-2(1H)-pyrazinones with acetoacetic ester was accompanied by further retro-Claisen fragmentation.
Keywords
Heterocycles , 3 , 5-Dichloro-2(1H)-pyrazinones , Acetoacetic ester , Malonate ester
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881656
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