Title of article
Stereoselective tribromomethylation of N-(tert-butanesulfinyl)imines with bromoform: practical synthesis of α-tribromomethyl amines
Author/Authors
Li، نويسنده , , Ya and Ma، نويسنده , , Yingchao and Lu، نويسنده , , Zhifeng and Wang، نويسنده , , Le and Ren، نويسنده , , Xinfeng and Sun، نويسنده , , Zhihua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4711
To page
4714
Abstract
The unprecedented nucleophilic tribromomethylation of N-(tert-butanesulfinyl)imines with bromoform has been shown to be a highly stereoselective and practical method for the synthesis of enantiomerically pure α-tribromomethyl amines. THF has proven to be the best solvent in this addition reaction. By changing the reaction solvent from THF to DMF, 2,2-dibromoaziridines can also be synthesized directly from bromoform and N-(tert-butanesulfinyl)imines under similar reaction conditions.
Keywords
Amines , diastereoselectivity , nucleophilic addition , Sulfinylimine , Tribromomethylation
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881670
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