Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas

N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (6a–q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (4a–e) with suitably substituted thioureas using microwave heating. The ethanones (4a–e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (3a–e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a–e) were synthesized by the reaction of 2-bromo-1-phenylethanones (2a–e) with thiazol-2-amine in refluxing acetone.