Title of article
Synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via a Pictet–Spengler approach
Author/Authors
Larsson، نويسنده , , Rikard and Blanco، نويسنده , , Narda and Johansson، نويسنده , , Martin and Sterner، نويسنده , , Olov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
4966
To page
4970
Abstract
A protocol for the diastereoselective synthesis of C-1 indol-3-yl substituted tetrahydroisoquinoline derivatives via Pictet–Spengler condensation with L-DOPA or l-DOPA derivatives and 1H-indole-3-carbaldehydes is presented. The protocol is used for the successful synthesis of several tetrahydroisoquinolines as well as diketopiperazine fused analogues.
Keywords
L-DOPA , 1H-Indole-3-carbaldehydes , C-1 Indolyl tetrahydroisoquinolines , Pictet–Spengler condensation , Diketopiperazine fused tetrahydroisoquinolines
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881892
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