Title of article
Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: the role of bases in promoting the formation of fluorescent S-acyl derivatives through S–N Smiles rearrangement
Author/Authors
Castagnolo، نويسنده , , Daniele and Pagano، نويسنده , , Mafalda and Bernardini، نويسنده , , Martina and Botta، نويسنده , , Maurizio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5008
To page
5011
Abstract
The acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan has been investigated. Depending on the use of the base, a competitive Smiles rearrangement occurs during the acylation step leading to the formation of N-acyl and/or fluorescent S-acyl derivatives. The acylating agent also affects the ratio of N/S acylated isomers.
Keywords
Benzofurazan , Smiles rearrangement , Fluorescent probe , cysteamine , S–N acylation
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881915
Link To Document