Title of article :
σ2-P Ligands: convenient syntheses of N-methyl-1,3-benzazaphospholes
Author/Authors :
Ghalib، نويسنده , , Mohammed and Niaz، نويسنده , , Basit and Jones، نويسنده , , Peter G. and Heinicke، نويسنده , , Joachim W.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
A convenient three-step route to 1,5-dimethyl-1,3-benzazaphosphole via Cu- or Pd-catalyzed phosphonylation of 2-iodo-4-methylaniline, reduction to 2-phosphino-4-methylaniline, and disproportionative cyclization with excess formaldehyde is reported. N-Methylbenzazaphospholes can be functionalized in the 2-position via α-CH-lithiation with tBuLi and are π-acidic σ2P-ligands.
Keywords :
Phosphonylation , Phosphinoaniline , Aromatic phosphorus heterocycles , P ligand , lithiation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
