Title of article
Artificial enzymes based on cyclodextrin with phenol as the catalytic group
Author/Authors
Lindbنck، نويسنده , , Emil and Zhou، نويسنده , , You and Pedersen، نويسنده , , Christian M. and Bols، نويسنده , , Mikael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5023
To page
5026
Abstract
β-Cyclodextrin containing one or two N-linked ortho-N-acetylaminophenols has been synthesized and tested for their properties as artificial glycosidases. Four different para-nitrophenyl glycosides were used as substrates and kcat/kuncat values of up to 381 were found for the di-functionalized products, whereas the mono derivative showed up to 47 times rate enhancement. The optimum pH for the catalysis was found to be approximately pH 8 and the influence of phosphate concentration was investigated.
Keywords
Chemzymes , Glycosidase , Catalysis , cyclodextrin
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881923
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