Title of article
Pd-catalyzed amination of 6-halo-2-cyclopropyl-3-(pyridyl-3-ylmethyl) quinazolin-4(3H)-one
Author/Authors
Garlapati، نويسنده , , Ramesh and Pottabathini، نويسنده , , Narender and Gurram، نويسنده , , Venkateshwarlu and Chaudhary، نويسنده , , Avinash B. and Chunduri، نويسنده , , Venkata Rao and Patro، نويسنده , , Balaram، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
5162
To page
5166
Abstract
6-Halo-2-cyclopropyl-3-(pyridyl-3-ylmethyl) quinazolin-4(3H)-one derivatives have been synthesized and utilized for amination reactions with aryl, heteroaryl and alkyl amines. Optimization of reaction conditions with different catalysts, ligands, bases, and solvents was conducted. The combination of Pd2(dba)3 with DavePhos (L3) proved to be best for these conversions in the presence of NaOtBu in 1,4-dioxane at 100 °C. The relative reactivities of 6-bromo and 6-chloro-2,3-disubstitued quinazolinones with p-toluidine were conducted and as anticipated the 6-bromo analogue was totally consumed and 6-chloro derivative was completely unreactive.
Keywords
amination , Modified quinazolinones , aryl , Heteroaryl , Alkyl amines , Relative reactivities , Pd2(dba)3DavePhos
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882011
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