Title of article
Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters
Author/Authors
Jida، نويسنده , , Mouhamad and Laconde، نويسنده , , Guillaume and Soueidan، نويسنده , , Olivier-Mohamad and Lebegue، نويسنده , , Nicolas and Revelant، نويسنده , , Germain and Pelinski، نويسنده , , Lydie and Agbossou-Niedercorn، نويسنده , , Francine and Deprez، نويسنده , , Benoît and Déprez-Poulain، نويسنده , , Rebecca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5215
To page
5218
Abstract
An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry.
Keywords
Nitrogen Heterocycles , Chiral , Stereoselective ring opening , cyclocondensation , lactams , Piperazines
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882046
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