Author/Authors :
Jida، نويسنده , , Mouhamad and Laconde، نويسنده , , Guillaume and Soueidan، نويسنده , , Olivier-Mohamad and Lebegue، نويسنده , , Nicolas and Revelant، نويسنده , , Germain and Pelinski، نويسنده , , Lydie and Agbossou-Niedercorn، نويسنده , , Francine and Deprez، نويسنده , , Benoît and Déprez-Poulain، نويسنده , , Rebecca، نويسنده ,
Abstract :
An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry.
Keywords :
Nitrogen Heterocycles , Chiral , Stereoselective ring opening , cyclocondensation , lactams , Piperazines
