Title of article
A novel approach for the synthesis of α-aminonitriles using Mitsunobu’s reagent under solvent-free conditions
Author/Authors
Chaturvedi، نويسنده , , Devdutt and Chaturvedi، نويسنده , , Amit K. and Mishra، نويسنده , , Nisha and Mishra، نويسنده , , Virendra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5398
To page
5401
Abstract
A highly efficient, one-pot, three-component, solvent-free protocol for the synthesis of α-aminonitriles starting from their corresponding carbonyl compounds, amines, using Mitsunobu’s reagent has been developed. Diversity of α-aminonitriles has been synthesized in good to excellent yields (80–99%) using various kinds of aldehydes/ketones and a variety of amines.
Keywords
carbonyl compounds , Mitsunobu’s reagent , Strecker’s synthesis , Amines , ?-aminonitriles
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882179
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