Title of article
Practical and high stereoselective synthesis of 3-(arylmethylene)isoindolin-1-ones from 2-formylbenzoic acid
Author/Authors
Reyes-Gonzلlez، نويسنده , , Miguel Angel and Zamudio-Medina، نويسنده , , Angel and Ordٌَez، نويسنده , , Mario، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
5756
To page
5758
Abstract
Practical and high stereoselective synthesis of 3-(arylmethylene)isoindolin-1-ones is reported. The synthetic method involves the preparation of dimethyl isoindolin-1-one-3-yl-phosphonates by a ‘one-pot’ three-component reaction of 2-formylbenzoic acid with 4-methoxybenzylamine or aminoacetaldehyde dimethyl acetal and dimethyl phosphite under solvent and catalyst free-conditions, followed by a Horner reaction with several aryl aldehydes.
Keywords
One-pot three-component reaction , 3-Methyleneisoindolin-1-ones , Horner reaction , 2-Formylbenzoic acid , Aminophosphonates
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882392
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