Title of article
Pavidolides A–E, new cembranoids from the soft coral Sinularia pavida
Author/Authors
Shen، نويسنده , , Shi and Zhu، نويسنده , , Huajie and Chen، نويسنده , , Dawei and Liu، نويسنده , , Dong and Ofwegen، نويسنده , , Leen van and Proksch، نويسنده , , Peter H. Lin، نويسنده , , Wenhan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5759
To page
5762
Abstract
Five new cembrane-based diterpenoids, namely pavidolides A–E (1–5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60.
Keywords
Antifouling activity , Structural elucidation , Soft coral , Sinularia pavida , cytotoxic activity , Pavidolides A–E
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882395
Link To Document