Title of article :
New potent vinca alkaloids resulting from an unexpected isomerization
Author/Authors :
Ngo، نويسنده , , Quoc Anh and Roussi، نويسنده , , Fanny and Thoret، نويسنده , , Sylviane and Guéritte، نويسنده , , Françoise، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Four new vinca alkaloids have been elaborated, using an unexpected isomerization and formation of stable enammoniums in very mild conditions. They are cytotoxic on a sub-micromolar range and inhibit microtubule assembly.
Keywords :
Enammoniums , Vinca alkaloids , Ammonium salts , Tubulin
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
