Title of article :
Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine-mediated formal [4+4] reaction of unsaturated imines
Author/Authors :
Tanaka، نويسنده , , Katsunori and Siwu، نويسنده , , Eric R.O. and Hirosaki، نويسنده , , Shinji and Iwata، نويسنده , , Takayuki and Matsumoto، نويسنده , , Risa and Kitagawa، نويسنده , , Yasutaka and Pradipta، نويسنده , , Ambara R. and Okumura، نويسنده , , Mitsutaka and Fukase، نويسنده , , Koichi، نويسنده ,
Abstract :
Formal [4+4] reaction of the unsaturated benzyl- or allylimines, which is efficiently mediated by primary amine, provides the 2,6,9-triazabicyclo[3.3.1]nonane derivatives. Variously substituted homo- and hetero-coupling products are obtained in good to excellent yields by quite a simple procedure under mild conditions: by mixing the unsaturated aldehydes with the amines at room temperature.
Keywords :
2 , Aminoacetal , Unsaturated imine , benzylamine , 6
