Title of article
Total synthesis of the COPD biomarker desmosine via Sonogashira and Negishi cross-coupling reactions
Author/Authors
Akira and Yanuma، نويسنده , , Hiroto and Usuki، نويسنده , , Toyonobu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
5920
To page
5922
Abstract
Desmosine, a crosslinking pyridinium amino acid of elastin, is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the total synthesis of (+)-desmosine is reported utilizing chemo- and regioselective Sonogashira and Negishi cross-coupling reactions in 15% yield over six steps.
Keywords
total synthesis , Sonogashira cross-coupling , Desmosine , Biomarker , Elastin , Negishi cross-coupling
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882502
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